Gastroesophageal Reflux Disease
PTSD/combat-stress and deployment exposures associated with gastroesophageal reflux disease in service members and veterans.
38 CFR diagnostic code 7346
Peer-reviewed evidence (38)
The verified studies behind a Gastroesophageal Reflux Disease claim — each links to its real PubMed or DOI record. These are sources our nexus drafts can draw from; none are invented.
- Koch TR, Emory TS. Evaluation of chronic gastrointestinal symptoms following Persian Gulf War exposure. Mil Med. 2005;170(8):696-700. PMID:16173212. doi:10.7205/milmed.170.8.696.
- Yousef A, Ahmed ST, H Nguyen Wenker T, Nono-Djotsa ABS, Boyle SH, Gifford EJ, Malhotra D, Chandler H, Bandi S, Helmer DA. Upper gastrointestinal symptoms and Gulf War Illness in a clinical cohort of US veterans: a retrospective, cross-sectional study. BMJ Open Gastroenterol. 2025;12(1):e001859. PMID:40912694. doi:10.1136/bmjgast-2025-001859.
- Wang WF, Guo XX, Yang YS. Gastrointestinal problems in modern wars: clinical features and possible mechanisms. Mil Med Res. 2015;2:15. PMID:26301101. doi:10.1186/s40779-015-0042-5.
- Daniele DO, Oh GT, O'Donnell FL, Clark LL. Incidence of gastroesophageal reflux disease (GERD), active component, U.S. Armed Forces, 2005-2014. MSMR. 2015;22(7):14-17. PMID:26207411.
- Tuteja AK, Talley NJ, Stoddard GJ, Samore MH, Verne GN. Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment. Neurogastroenterol Motil. 2019;31(3):e13533. PMID:30697884. doi:10.1111/nmo.13533.
- Porter CK, Gloor K, Cash BD, Riddle MS. Risk of functional gastrointestinal disorders in U.S. military following self-reported diarrhea and vomiting during deployment. Dig Dis Sci. 2011;56(11):3262-3269. PMID:21643738. doi:10.1007/s10620-011-1762-3.
- Maule AL, Janulewicz PA, Sullivan KA, Krengel MH, Yee MK, McClean M, White RF. Meta-analysis of self-reported health symptoms in 1990-1991 Gulf War and Gulf War-era veterans. BMJ Open. 2018;8(2):e016086. PMID:29440208. doi:10.1136/bmjopen-2017-016086.
- Herregods TV, van Hoeij FB, Oors JM, Bredenoord AJ, Smout AJ. Effect of Running on Gastroesophageal Reflux and Reflux Mechanisms. Am J Gastroenterol. 2016;111(7):940-6. PMID:27068716. doi:10.1038/ajg.2016.122.
- Schey R, Dickman R, Parthasarathy S, Quan SF, Wendel C, Merchant J, Powers J, Han B, van Handel D, Fass R. Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux disease. Gastroenterology. 2007;133(6):1787-95. PMID:18054551. doi:10.1053/j.gastro.2007.09.039.
- Chung TH, Lee J, Kim MC. Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers. Int Arch Occup Environ Health. 2016;89(6):961-966. PMID:27129469. doi:10.1007/s00420-016-1130-x.
- Fujiwara Y, Machida A, Watanabe Y, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T. Association between dinner-to-bed time and gastro-esophageal reflux disease. Am J Gastroenterol. 2005;100(12):2633-2636. PMID:16393212. doi:10.1111/j.1572-0241.2005.00354.x.
- Wickramasinghe N, Thuraisingham A, Jayalath A, Wickramasinghe D, Samarasekara N, Yazaki E, Devanarayana NM. The association between symptoms of gastroesophageal reflux disease and perceived stress: A countrywide study of Sri Lanka. PLoS One. 2023;18(11):e0294135. PMID:37943748. doi:10.1371/journal.pone.0294135.
- Okuyama M, Takaishi O, Nakahara K, Iwakura N, Hasegawa T, Oyama M, Inoue A, Ishizu H, Satoh H, Fujiwara Y. Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults. Scand J Gastroenterol. 2017;52(1):44-49. PMID:27571846. doi:10.1080/00365521.2016.1224383.
- Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011;62(6):591-599. PMID:22314561.
- Chen HT, Chuang HY, Hsieh TY, Wu PS, Lin FJ, Huang HC, Yang CC, Kuo CH. Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study. Front Public Health. 2022;10(n/a (article number series)):980603. PMID:36504996. doi:10.3389/fpubh.2022.980603.
- Xue J, Zhao Y, Wang Z, Ren N, Zhou C, Qin S. Rotating night shift work is associated with an increased risk of gastroesophageal reflux disease (GERD) symptoms among workers in China: A cross-sectional study. Int J Clin Pract. 2021;75(4):e13848. PMID:33220144. doi:10.1111/ijcp.13848.
- Ness-Jensen E, Hveem K, El-Serag H, Lagergren J. Lifestyle Intervention in Gastroesophageal Reflux Disease. Clin Gastroenterol Hepatol. 2016;14(2):175-182.e1-3. PMID:25956834. doi:10.1016/j.cgh.2015.04.176.
- de la Hoz RE, Christie J, Teamer JA, Bienenfeld LA, Afilaka AA, Crane M, Levin SM, Herbert R. Reflux symptoms and disorders and pulmonary disease in former World Trade Center rescue and recovery workers and volunteers. J Occup Environ Med. 2008;50(12):1351-1354. PMID:19092489. doi:10.1097/JOM.0b013e3181845f9b.
- Malhotra D, Boyle SH, Gifford EJ, Sullivan BA, Nguyen Wenker TH, Abs ND, Ahmed ST, Upchurch J. Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder. Neurogastroenterol Motil. 2023;35(5):e14548. PMID:36942766. doi:10.1111/nmo.14548.
- Guadagnoli L, Mashimo H, Lo WK. Assessment of Post-traumatic Stress Disorder Among Objective Esophageal Motility and Reflux Phenotypes in Symptomatic Veterans. J Clin Psychol Med Settings. 2023;30(3):606-617. PMID:36378471. doi:10.1007/s10880-022-09920-6.
- Li J, Brackbill RM, Stellman SD, Farfel MR, Miller-Archie SA, Friedman S, Walker DJ, Thorpe LE. Gastroesophageal reflux symptoms and comorbid asthma and posttraumatic stress disorder following the 9/11 terrorist attacks on World Trade Center in New York City. Am J Gastroenterol. 2011;106(11):1933-41. PMID:21894225. doi:10.1038/ajg.2011.300.
- Litcher-Kelly L, Lam Y, Broihier JA, Brand DL, Banker SV, Kotov R, Bromet E, Bucobo JC. Longitudinal study of the impact of psychological distress symptoms on new-onset upper gastrointestinal symptoms in World Trade Center responders. Psychosom Med. 2014;76(9):686-93. PMID:25373890. doi:10.1097/PSY.0000000000000116.
- Li C, Wu ZH, Pan XL, Yuan K. Effect of continuous positive airway pressure on gastroesophageal reflux in patients with obstructive sleep apnea: a meta-analysis. Sleep Breath. 2021;25(3):1203-1210. PMID:33118054. doi:10.1007/s11325-020-02224-9.
- El Hage Chehade N, Fu Y, Ghoneim S, Shah S, Song G, Fass R. Association between obstructive sleep apnea and gastroesophageal reflux disease: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2023;38(8):1244-1251. PMID:37300443. doi:10.1111/jgh.16245.
- Feng Z, Wu S, Wang M, Wang H, Hou Y, Yi H, Xiao F, Xu L, Dong X, Han F. A high arousal threshold is associated with nocturnal gastroesophageal reflux in obstructive sleep apnea. Sleep Med. 2025;129:297-305. PMID:40081280. doi:10.1016/j.sleep.2025.03.004.
- Watson NF, Mystkowski SK. Aerophagia and gastroesophageal reflux disease in patients using continuous positive airway pressure: a preliminary observation. J Clin Sleep Med. 2008;4(5):434-8. PMID:18853700.
- Kuribayashi S, Kusano M, Kawamura O, Shimoyama Y, Maeda M, Hisada T, Ishizuka T, Dobashi K, Mori M. Mechanism of gastroesophageal reflux in patients with obstructive sleep apnea syndrome. Neurogastroenterol Motil. 2010;22(6):611-e172. PMID:20236246. doi:10.1111/j.1365-2982.2010.01485.x.
- Dent J, Holloway RH, Eastwood PR. Systematic review: relationships between sleep and gastro-oesophageal reflux. Aliment Pharmacol Ther. 2013;38(7):657-73. PMID:23957437. doi:10.1111/apt.12445.
- Tawk M, Goodrich S, Kinasewitz G, Orr W. The effect of 1 week of continuous positive airway pressure treatment in obstructive sleep apnea patients with concomitant gastroesophageal reflux. Chest. 2006;130(4):1003-8. PMID:17035431.
- Elfanagely Y, Atsawarungruangkit A, Scharfen J, Pavlech L, Moss SF. Association Between Obstructive Sleep Apnea and Barrett's Esophagus: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2021;66(11):3689-3697. PMID:33236316. doi:10.1007/s10620-020-06709-1.
- Wu ZH, Yang XP, Niu X, Xiao XY, Chen X. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath. 2019;23(2):389-397. PMID:29987514. doi:10.1007/s11325-018-1691-x.
- Emilsson OI, Janson C, Benediktsdottir B, Juliusson S, Gislason T. Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey. Respir Med. 2012;106(3):459-66. PMID:22197048. doi:10.1016/j.rmed.2011.12.004.
- Shepherd K, Hillman D, Eastwood P. Symptoms of aerophagia are common in patients on continuous positive airway pressure therapy and are related to the presence of nighttime gastroesophageal reflux. J Clin Sleep Med. 2013;9(1):13-7. PMID:23319899. doi:10.5664/jcsm.2328.
- Shepherd K, Hillman D, Holloway R, Eastwood P. Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea. Sleep Breath. 2011;15(3):561-70. PMID:20711680. doi:10.1007/s11325-010-0404-x.
- Demeter P, Pap A. The relationship between gastroesophageal reflux disease and obstructive sleep apnea. J Gastroenterol. 2004;39(9):815-20. PMID:15565398.
- Lim KG, Morgenthaler TI, Katzka DA. Sleep and Nocturnal Gastroesophageal Reflux: An Update. Chest. 2018;154(4):963-971. PMID:29859888. doi:10.1016/j.chest.2018.05.030.
- Friedman M, Gurpinar B, Lin HC, Schalch P, Joseph NJ. Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. Ann Otol Rhinol Laryngol. 2007;116(11):805-11. PMID:18074664. doi:10.1177/000348940711601103.
- Shepherd K, Orr W. Mechanism of Gastroesophageal Reflux in Obstructive Sleep Apnea: Airway Obstruction or Obesity? J Clin Sleep Med. 2016;12(1):87-94. PMID:26446244. doi:10.5664/jcsm.5402.
Controlling law
The CFR sections and cases the theories relevant to this condition rest on — the legal standard raters evaluate against, never a prediction about any claim.
Direct (§ 3.303)
Regulation
38 C.F.R. § 3.303
Direct service connection — a current disability linked to service. (Continuity of symptomatology under § 3.303(b) is limited by case law to the § 3.309(a) chronic diseases — Walker.)
Case law
Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004)
The three-element test: current disability, in-service event, and a nexus between them.
Holton v. Shinseki, 557 F.3d 1363 (Fed. Cir. 2009)
Federal Circuit restatement of the same three direct-service-connection elements.
Caluza v. Brown, 7 Vet. App. 498 (1995)
The evidentiary framework a rater weighs each element against.
Walker v. Shinseki, 708 F.3d 1331 (Fed. Cir. 2013)
Continuity of symptomatology (§ 3.303(b)) is available ONLY for a chronic disease listed in § 3.309(a); any other condition must use the medical-nexus pathway.
Davidson v. Shinseki, 581 F.3d 1313 (Fed. Cir. 2009)
A categorical 'a medical opinion is always required for nexus' is legal error — competent lay evidence can suffice.
Jandreau v. Nicholson, 492 F.3d 1372 (Fed. Cir. 2007); Layno v. Brown, 6 Vet. App. 465 (1994)
A veteran is competent to report symptoms they personally observe (Layno), and lay evidence can even establish a simple diagnosis in the right case (Jandreau).
McLendon v. Nicholson, 20 Vet. App. 79 (2006)
A LOW threshold — evidence that merely indicates a nexus MAY exist obligates VA to provide a C&P exam.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Secondary (§ 3.310)
Regulation
38 C.F.R. § 3.310(a)
A condition proximately caused by a service-connected condition (or by the treatment it requires).
38 C.F.R. § 3.310(b)
A condition worsened beyond its natural progression by a service-connected condition.
Case law
Wallin v. West, 11 Vet. App. 509 (1998)
The three secondary elements: a current disability, a service-connected disability, and medical-nexus evidence linking them.
Allen v. Brown, 7 Vet. App. 439 (1995)
Secondary aggravation is compensable for the degree of worsening over the pre-aggravation baseline.
El-Amin v. Shinseki, 26 Vet. App. 136 (2013)
An opinion addressing only causation is inadequate where aggravation is also raised — the letter must speak to both prongs.
Spicer v. McDonough, 61 F.4th 1360 (Fed. Cir. 2023)
Expanded what qualifies (severity-worsening and treatment-based theories suffice; a § 3.310(b) baseline/permanence objection cannot defeat a but-for severity theory). Not a heightened standard.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Aggravation (§ 3.306)
Regulation
38 C.F.R. § 3.306 (38 U.S.C. § 1153)
DIRECT aggravation: a pre-existing condition NOTED AT ENTRY that increased in disability during service — unless the increase is due to the natural progress of the disease. An in-service increase raises a PRESUMPTION of aggravation VA must rebut.
38 C.F.R. § 3.310(b)
SECONDARY aggravation (a distinct branch): a non-service-connected condition worsened by an already service-connected condition — see Allen.
Case law
Wagner v. Principi, 370 F.3d 1089 (Fed. Cir. 2004)
If the condition was NOT noted at entry, the veteran is presumed sound; VA must rebut BOTH pre-existence and lack of aggravation by clear and unmistakable EVIDENCE (not the CUE error doctrine). If VA fails, the claim proceeds as ordinary DIRECT service connection — not as an aggravation claim.
Horn v. Shinseki, 25 Vet. App. 231 (2012)
That rebuttal burden never shifts back to the veteran — VA must rely on affirmative evidence of no aggravation.
Hunt v. Derwinski, 1 Vet. App. 292 (1991); Davis v. Principi, 276 F.3d 1341 (Fed. Cir. 2002)
Temporary flare-ups are not aggravation — the UNDERLYING condition (not just symptoms) must have worsened.
Allen v. Brown, 7 Vet. App. 439 (1995)
Compensation is for the measurable degree of worsening over the established baseline.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Presumptive (§ 3.307–3.309)
Regulation
38 C.F.R. §§ 3.307, 3.309
Presumptive service connection — the link is presumed by law for qualifying service/exposure; no nexus opinion is needed.
38 C.F.R. §§ 3.317, 3.320
Gulf War undiagnosed / chronic multisymptom illness (§ 3.317), and burn-pit / particulate-matter presumptions (§ 3.320).
38 U.S.C. §§ 1116, 1117, 1119, 1120
Herbicide (incl. PACT-added hypertension), Gulf War illness, the presumption of EXPOSURE for covered veterans, and burn-pit disease presumptions.
Case law
Combee v. Brown, 34 F.3d 1039 (Fed. Cir. 1994)
The presumptive path is NOT exclusive — a veteran may ALSO prove direct causation the ordinary way.
Gutierrez v. Principi, 19 Vet. App. 1 (2004)
A § 3.317 Gulf War claim needs no nexus evidence — lay-observable symptoms suffice.
Procopio v. Wilkie, 913 F.3d 1371 (Fed. Cir. 2019) (en banc)
Blue Water Navy veterans are covered by the herbicide presumption.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
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