Obstructive Sleep Apnea
Deployment-associated OSA risk and rising in-service incidence, plus the sleep-restriction and sleep-fragmentation physiology that reduces genioglossus drive and raises upper-airway collapsibility — supporting DIRECT service connection; with the PTSD, nasal-obstruction, post-injury weight-gain, and TBI pathways supporting secondary service connection.
38 CFR diagnostic code 6847
Peer-reviewed evidence (51)
The verified studies behind an Obstructive Sleep Apnea claim — each links to its real PubMed or DOI record. These are sources our nexus drafts can draw from; none are invented.
- Mysliwiec V, Gill J, Lee H, Baxter T, Pierce R, Barr TL, Krakow B, Roth BJ. Sleep disorders in US military personnel: a high rate of comorbid insomnia and obstructive sleep apnea. Chest. 2013;144(2):549-557. PMID:23681455. doi:10.1378/chest.13-0088.
- Colvonen PJ, Masino T, Drummond SP, Myers US, Angkaw AC, Norman SB. Obstructive sleep apnea and posttraumatic stress disorder among OEF/OIF/OND veterans. J Clin Sleep Med. 2015;11(5):513-518. PMID:25665698. doi:10.5664/jcsm.4692.
- Figorilli M, Velluzzi F, Redolfi S. Obesity and sleep disorders: A bidirectional relationship. Nutr Metab Cardiovasc Dis. 2025;35(6):104014. PMID:40180826. doi:10.1016/j.numecd.2025.104014.
- Landvater J, Kim S, Caswell K, Kwon C, Odafe E, Roe G, Tripathi A, Vukovics C. Traumatic brain injury and sleep in military and veteran populations: A literature review. NeuroRehabilitation. 2024;55(3):245-270. PMID:39121144. doi:10.3233/NRE-230380.
- Caldwell JA, Knapik JJ, Shing TL, Kardouni JR, Lieberman HR. The association of insomnia and sleep apnea with deployment and combat exposure in the entire population of US army soldiers from 1997 to 2011: a retrospective cohort investigation. Sleep. 2019;42(8):zsz112. PMID:31106808. doi:10.1093/sleep/zsz112.
- Caldwell JA, Knapik JJ, Kusumpa S, Roy TC, Taylor KM, Lieberman HR. Insomnia and sleep apnea in the entire population of US Army soldiers: Associations with deployment and combat exposure 2010-2019, a retrospective cohort investigation. Sleep Health. 2025;11(1):14-24. PMID:39438179. doi:10.1016/j.sleh.2024.09.004.
- Moore BA, Tison LM, Palacios JG, Peterson AL, Mysliwiec V. Incidence of insomnia and obstructive sleep apnea in active duty United States military service members. Sleep. 2021;44(7):zsab024. PMID:33532830. doi:10.1093/sleep/zsab024.
- Goldstein LA, Bernhard PA, Hoffmire CA, Schneiderman A, Maguen S. Prevalence of Obstructive Sleep Apnea Among Veterans and Nonveterans. Am J Health Promot. 2025;39(2):215-223. PMID:39136615. doi:10.1177/08901171241273443.
- Alexander M, Ray MA, Hébert JR, Youngstedt SD, Zhang H, Steck SE, Bogan RK, Burch JB. The National Veteran Sleep Disorder Study: Descriptive Epidemiology and Secular Trends, 2000-2010. Sleep. 2016;39(7):1399-1410. PMID:27091538. doi:10.5665/sleep.5972.
- Huang Y, Xu J, Zheng S, Xu S, Wang Y, Du J, Xiao L, Zhang R, Wang H, Tang Y, Su T. The risk factors for insomnia and sleep-disordered breathing in military communities: A meta-analysis. PLoS One. 2021;16(5):e0250779. PMID:33956821. doi:10.1371/journal.pone.0250779.
- Mysliwiec V, McGraw L, Pierce R, Smith P, Trapp B, Roth BJ. Sleep disorders and associated medical comorbidities in active duty military personnel. Sleep. 2013;36(2):167-174. PMID:23372263. doi:10.5665/sleep.2364.
- Mysliwiec V, Brock MS, Pruiksma KE, Straud CL, Taylor DJ, Hansen S, Foster SN, Mithani S, Zwetzig S, Gerwell K, Young-McCaughan S, Powell T, Blue Star JA, Cassidy DG, Mintz J, Peterson AL. A comprehensive evaluation of insomnia, obstructive sleep apnea and comorbid insomnia and obstructive sleep apnea in US military personnel. Sleep. 2022;45(12):zsac203. PMID:36006786. doi:10.1093/sleep/zsac203.
- Mysliwiec V, Pruiksma KE, Brock MS, Straud C, Taylor DJ, Hansen S, Foster SN, Gerwell K, Moore BA, Carrizales FA, Young-McCaughan S, Vanecek R, Mintz J, Peterson AL. The Military Service Sleep Assessment: an instrument to assess factors precipitating sleep disturbances in U.S. military personnel. J Clin Sleep Med. 2021;17(7):1401-1409. PMID:33682675. doi:10.5664/jcsm.9206.
- Matsangas P, Shattuck NL. Sleep quality, occupational factors, and psychomotor vigilance performance in the U.S. Navy sailors. Sleep. 2020;43(12):zsaa118. PMID:32531020. doi:10.1093/sleep/zsaa118.
- Leiter JC, Knuth SL, Bartlett D Jr. The effect of sleep deprivation on activity of the genioglossus muscle. Am Rev Respir Dis. 1985;132(6):1242-1245. PMID:3935019. doi:10.1164/arrd.1985.132.6.1242.
- Sériès F, Roy N, Marc I. Effects of sleep deprivation and sleep fragmentation on upper airway collapsibility in normal subjects. Am J Respir Crit Care Med. 1994;150(2):481-485. PMID:8049833. doi:10.1164/ajrccm.150.2.8049833.
- Persson HE, Svanborg E. Sleep deprivation worsens obstructive sleep apnea. Comparison between diurnal and nocturnal polysomnography. Chest. 1996;109(3):645-650. PMID:8617071. doi:10.1378/chest.109.3.645.
- Caldwell JA, Knapik JJ. Trends and Factors Associated with Insomnia and Sleep Apnea in U.S. Military Aviators, 2006-2022. Aerosp Med Hum Perform. 2025;96(1):23-30. PMID:39853290. doi:10.3357/AMHP.6524.2024.
- Capener DC, Brock MS, Hansen SL, Matsangas P, Mysliwiec V. An Initial Report of Sleep Disorders in Women in the U.S. Military. Mil Med. 2018;183(9-10):e266-e271. PMID:29425355. doi:10.1093/milmed/usx116.
- Young T, Finn L, Palta M. Chronic nasal congestion at night is a risk factor for snoring in a population-based cohort study. Arch Intern Med. 2001;161(12):1514-1519. PMID:11427099. doi:10.1001/archinte.161.12.1514.
- Young T, Finn L, Kim H. Nasal obstruction as a risk factor for sleep-disordered breathing. The University of Wisconsin Sleep and Respiratory Research Group. J Allergy Clin Immunol. 1997;99(2):S757-S762. PMID:9042068. doi:10.1016/s0091-6749(97)70124-6.
- Ferreira NB, Ponte A, Castelo Grande A, Pimenta AC, Pinto CS, Bousquet J, Drummond M, Sousa-Pinto B. Frequency of obstructive sleep apnea in patients with asthma or allergic rhinitis: a systematic review and meta-analysis. Sleep Med. 2025;134:106705. PMID:40774162. doi:10.1016/j.sleep.2025.106705.
- Camacho M, Riaz M, Capasso R, Ruoff CM, Guilleminault C, Kushida CA, Certal V. The effect of nasal surgery on continuous positive airway pressure device use and therapeutic treatment pressures: a systematic review and meta-analysis. Sleep. 2015;38(2):279-286. PMID:25325439. doi:10.5665/sleep.4414.
- Wu J, Zhao G, Li Y, Zang H, Wang T, Wang D, Han D. Apnea-hypopnea index decreased significantly after nasal surgery for obstructive sleep apnea: A meta-analysis. Medicine (Baltimore). 2017;96(5):e6008. PMID:28151900. doi:10.1097/MD.0000000000006008.
- Cha H, Kim D, Lee HW, Lee Y, Baek BJ, Lee JY, Choi JH. Relationship between chronic rhinosinusitis and risk of obstructive sleep apnea. Sci Rep. 2024;14(1):21379. PMID:39271710. doi:10.1038/s41598-024-71923-0.
- Fried J, Yuen E, Li A, Zhang K, Nguyen SA, Gudis DA, Rowan NR, Schlosser RJ. Rhinologic disease and its impact on sleep: a systematic review. Int Forum Allergy Rhinol. 2021;11(7):1074-1086. PMID:33275331. doi:10.1002/alr.22740.
- Wellman A, Genta PR, Owens RL, Edwards BA, Sands SA, Loring SH, White DP, Jackson AC, Pedersen OF, Butler JP. Test of the Starling resistor model in the human upper airway during sleep. J Appl Physiol (1985). 2014;117(12):1478-1485. PMID:25324514. doi:10.1152/japplphysiol.00259.2014.
- Garvey E, Duffy A, Tekumalla S, Naimi B, Kahn C, Yang A, Urdang Z, Farquhar D, Rosen M, Nyquist GG, Toskala E, Rabinowitz M. Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden. Otolaryngol Head Neck Surg. 2024;171(6):1879-1886. PMID:39575579. doi:10.1002/ohn.934.
- Cai Y, Goldberg AN, Chang JL. The Nose and Nasal Breathing in Sleep Apnea. Otolaryngol Clin North Am. 2020;53(3):385-395. PMID:32192710. doi:10.1016/j.otc.2020.02.002.
- Ishii L, Roxbury C, Godoy A, Ishman S, Ishii M. Does Nasal Surgery Improve OSA in Patients with Nasal Obstruction and OSA? A Meta-analysis. Otolaryngol Head Neck Surg. 2015;153(3):326-333. PMID:26183522. doi:10.1177/0194599815594374.
- Cao Y, Wu S, Zhang L, Yang Y, Cao S, Li Q. Association of allergic rhinitis with obstructive sleep apnea: A meta-analysis. Medicine (Baltimore). 2018;97(51):e13783. PMID:30572534. doi:10.1097/MD.0000000000013783.
- Georgalas C. The role of the nose in snoring and obstructive sleep apnoea: an update. Eur Arch Otorhinolaryngol. 2011;268(9):1365-1373. PMID:21340561. doi:10.1007/s00405-010-1469-7.
- Yang H, Huyett P, Wang TY, Sumner J, Azarbarzin A, Labarca GPT, Messineo L, Gell LK, Aishah A, Hu WH, White DP, Sands SA, Wellman A, Vena D. Mouth Closure and Airflow in Patients With Obstructive Sleep Apnea: A Nonrandomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2024;150(11):1012-1019. PMID:39361293. doi:10.1001/jamaoto.2024.3319.
- Shah AJ, Vaccarino V, Goldberg J, Huang M, Ko YA, Ma X, Levantsevych OM, Smith NL, Alagar N, Mousselli I, Johnson DA, Clifford GD, Bremner JD, Bliwise DL. Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins. JAMA Netw Open. 2024;7(6):e2416352. PMID:38913378. doi:10.1001/jamanetworkopen.2024.16352.
- Haynes ZA, Stewart IJ, Poltavskiy EA, Holley AB, Janak JC, Howard JT, Watrous J, Walker LE, Wickwire EM, Werner K, Zarzabal LA, Sim A, Gundlapalli A, Collen JF. Obstructive sleep apnea among survivors of combat-related traumatic injury: a retrospective cohort study. J Clin Sleep Med. 2022;18(1):171-179. PMID:34270410. doi:10.5664/jcsm.9530.
- Chinoy ED, Carey FR, Kolaja CA, Jacobson IG, Cooper AD, Markwald RR. The bi-directional relationship between post-traumatic stress disorder and obstructive sleep apnea and/or insomnia in a large U.S. military cohort. Sleep Health. 2022;8(6):606-614. PMID:36163136. doi:10.1016/j.sleh.2022.07.005.
- Zhang Y, Weed JG, Ren R, Tang X, Zhang W. Prevalence of obstructive sleep apnea in patients with posttraumatic stress disorder and its impact on adherence to continuous positive airway pressure therapy: a meta-analysis. Sleep Med. 2017;36:125-132. PMID:28735910. doi:10.1016/j.sleep.2017.04.020.
- Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med. 2015;11(2):165-75. PMID:25406268. doi:10.5664/jcsm.4466.
- Lyons R, Barbir LA, Owens R, Colvonen PJ. STOP-BANG screener vs objective obstructive sleep apnea testing among younger veterans with PTSD and insomnia: STOP-BANG does not sufficiently detect risk. J Clin Sleep Med. 2022;18(1):67-73. PMID:34216197. doi:10.5664/jcsm.9498.
- Noland MDW, Paolillo EW, Noda A, Lazzeroni LC, Holty JC, Kuschner WG, Yesavage J, Kinoshita LM. Impact of PTSD and Obstructive Sleep Apnea on Cognition in Older Adult Veterans. J Geriatr Psychiatry Neurol. 2023;36(5):386-396. PMID:36592096. doi:10.1177/08919887221149132.
- van Liempt S, Arends J, Cluitmans PJM, Westenberg HGM, Kahn RS, Vermetten E. Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling. Psychoneuroendocrinology. 2013;38(1):155-65. PMID:22776420. doi:10.1016/j.psyneuen.2012.05.015.
- Kaplan GB, Lakis GA, Zhoba H. Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems. Brain Res Bull. 2022;186:106-122. PMID:35618150. doi:10.1016/j.brainresbull.2022.05.006.
- Zhang Y, Ren R, Yang L, Zhou J, Sanford LD, Tang X. The effect of treating obstructive sleep apnea with continuous positive airway pressure on posttraumatic stress disorder: A systematic review and meta-analysis with hypothetical model. Neurosci Biobehav Rev. 2019;102:172-183. PMID:31042558. doi:10.1016/j.neubiorev.2019.03.019.
- Gafoor R, Booth HP, Gulliford MC. Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study. BMJ. 2018;361:k1951. PMID:29793997. doi:10.1136/bmj.k1951.
- Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284(23):3015-21. PMID:11122588.
- Jha A, Sharma SK, Tandon N, Lakshmy R, Kadhiravan T, Handa KK, Gupta R, Pandey RM, Chaturvedi PK. Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism. Sleep Med. 2006;7(1):55-61. PMID:16198143.
- Zhang M, Zhang W, Tan J, Zhao M, Zhang Q, Lei P. Role of hypothyroidism in obstructive sleep apnea: a meta-analysis. Curr Med Res Opin. 2016;32(6):1059-64. PMID:26907534. doi:10.1185/03007995.2016.1157461.
- Lu N, Chen B. Causal association between hypothyroidism and obstructive sleep apnea: A bidirectional 2-sample Mendelian Randomization study. Medicine (Baltimore). 2024;103(42):e40114. PMID:39432624. doi:10.1097/MD.0000000000040114.
- Zhang H, Wu Z, Chen Q, Yu G, Chen L, Ma Y, Chen Y. Subtype-specific causal effects of hypothyroidism on obstructive sleep apnea: A bidirectional Mendelian randomization study. Medicine (Baltimore). 2025;104(27):e43266. PMID:40629611. doi:10.1097/MD.0000000000043266.
- Pancholi C, Chaudhary SC, Gupta KK, Sawlani KK, Verma SK, Singh A, Verma AK, Usman K, Atam V. Obstructive sleep apnea in hypothyroidism. Ann Afr Med. 2022;21(4):403-409. PMID:36412342. doi:10.4103/aam.aam_134_21.
- Kuczyński W, Gabryelska A, Mokros Ł, Białasiewicz P. Obstructive sleep apnea syndrome and hypothyroidism — merely concurrence or causal association?. Pneumonol Alergol Pol. 2016;84(5):302-6. PMID:27672073. doi:10.5603/PiAP.2016.0038.
Controlling law
The CFR sections and cases the theories relevant to this condition rest on — the legal standard raters evaluate against, never a prediction about any claim.
Direct (§ 3.303)
Regulation
38 C.F.R. § 3.303
Direct service connection — a current disability linked to service. (Continuity of symptomatology under § 3.303(b) is limited by case law to the § 3.309(a) chronic diseases — Walker.)
Case law
Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004)
The three-element test: current disability, in-service event, and a nexus between them.
Holton v. Shinseki, 557 F.3d 1363 (Fed. Cir. 2009)
Federal Circuit restatement of the same three direct-service-connection elements.
Caluza v. Brown, 7 Vet. App. 498 (1995)
The evidentiary framework a rater weighs each element against.
Walker v. Shinseki, 708 F.3d 1331 (Fed. Cir. 2013)
Continuity of symptomatology (§ 3.303(b)) is available ONLY for a chronic disease listed in § 3.309(a); any other condition must use the medical-nexus pathway.
Davidson v. Shinseki, 581 F.3d 1313 (Fed. Cir. 2009)
A categorical 'a medical opinion is always required for nexus' is legal error — competent lay evidence can suffice.
Jandreau v. Nicholson, 492 F.3d 1372 (Fed. Cir. 2007); Layno v. Brown, 6 Vet. App. 465 (1994)
A veteran is competent to report symptoms they personally observe (Layno), and lay evidence can even establish a simple diagnosis in the right case (Jandreau).
McLendon v. Nicholson, 20 Vet. App. 79 (2006)
A LOW threshold — evidence that merely indicates a nexus MAY exist obligates VA to provide a C&P exam.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Secondary (§ 3.310)
Regulation
38 C.F.R. § 3.310(a)
A condition proximately caused by a service-connected condition (or by the treatment it requires).
38 C.F.R. § 3.310(b)
A condition worsened beyond its natural progression by a service-connected condition.
Case law
Wallin v. West, 11 Vet. App. 509 (1998)
The three secondary elements: a current disability, a service-connected disability, and medical-nexus evidence linking them.
Allen v. Brown, 7 Vet. App. 439 (1995)
Secondary aggravation is compensable for the degree of worsening over the pre-aggravation baseline.
El-Amin v. Shinseki, 26 Vet. App. 136 (2013)
An opinion addressing only causation is inadequate where aggravation is also raised — the letter must speak to both prongs.
Spicer v. McDonough, 61 F.4th 1360 (Fed. Cir. 2023)
Expanded what qualifies (severity-worsening and treatment-based theories suffice; a § 3.310(b) baseline/permanence objection cannot defeat a but-for severity theory). Not a heightened standard.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Aggravation (§ 3.306)
Regulation
38 C.F.R. § 3.306 (38 U.S.C. § 1153)
DIRECT aggravation: a pre-existing condition NOTED AT ENTRY that increased in disability during service — unless the increase is due to the natural progress of the disease. An in-service increase raises a PRESUMPTION of aggravation VA must rebut.
38 C.F.R. § 3.310(b)
SECONDARY aggravation (a distinct branch): a non-service-connected condition worsened by an already service-connected condition — see Allen.
Case law
Wagner v. Principi, 370 F.3d 1089 (Fed. Cir. 2004)
If the condition was NOT noted at entry, the veteran is presumed sound; VA must rebut BOTH pre-existence and lack of aggravation by clear and unmistakable EVIDENCE (not the CUE error doctrine). If VA fails, the claim proceeds as ordinary DIRECT service connection — not as an aggravation claim.
Horn v. Shinseki, 25 Vet. App. 231 (2012)
That rebuttal burden never shifts back to the veteran — VA must rely on affirmative evidence of no aggravation.
Hunt v. Derwinski, 1 Vet. App. 292 (1991); Davis v. Principi, 276 F.3d 1341 (Fed. Cir. 2002)
Temporary flare-ups are not aggravation — the UNDERLYING condition (not just symptoms) must have worsened.
Allen v. Brown, 7 Vet. App. 439 (1995)
Compensation is for the measurable degree of worsening over the established baseline.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Build your Obstructive Sleep Apnea documentation
Generate and review your claim documents free — grounded in sources like these. When you want the nexus opinion signed, a licensed provider can review and sign it.
Generate your documentation — freeEducational information about the evidentiary standard — not legal or medical advice, and never a prediction about any claim.