Agent Orange Presumptive Conditions List and Locations (2026)

VA presumes the following conditions were caused by Agent Orange for a veteran with qualifying service: AL amyloidosis, bladder cancer, chloracne, chronic B-cell leukemias, type 2 diabetes, Hodgkin's disease, hypertension, hypothyroidism, ischemic heart disease, MGUS, multiple myeloma, non-Hodgkin's lymphoma, Parkinson's disease, Parkinsonism, early-onset peripheral neuropathy, porphyria cutanea tarda, prostate cancer, respiratory cancers, and soft-tissue sarcomas. Qualifying service starts with Vietnam (January 9, 1962 to May 7, 1975) and now includes the Blue Water Navy, the Korean DMZ, Thailand, Laos, parts of Cambodia, Guam, American Samoa, and Johnston Atoll, each with its own dates below.

If you have one of these conditions and the service to match, you do not need a nexus letter to connect it to herbicide exposure. You need the diagnosis and proof of where and when you served.

The conditions, and where each one comes from

Most of the list is in VA's regulation, 38 C.F.R. § 3.309(e):

• AL amyloidosis
• Chloracne or other acneform disease consistent with chloracne
• Type 2 diabetes (see the type 2 diabetes and Agent Orange guide)
• Hodgkin's disease
• Ischemic heart disease, including heart attack, coronary artery disease, coronary bypass surgery, and stable, unstable, and Prinzmetal's angina
• All chronic B-cell leukemias, including hairy-cell leukemia and chronic lymphocytic leukemia
• Multiple myeloma
• Non-Hodgkin's lymphoma
• Parkinson's disease
• Early-onset peripheral neuropathy
• Porphyria cutanea tarda
• Prostate cancer
• Respiratory cancers: cancer of the lung, bronchus, larynx, or trachea
• Soft-tissue sarcomas, other than osteosarcoma, chondrosarcoma, Kaposi's sarcoma, or mesothelioma

Five more were added by Congress directly in the statute, 38 U.S.C. § 1116:

• Bladder cancer
• Hypothyroidism
• Parkinsonism
• Monoclonal gammopathy of undetermined significance (MGUS), added by the PACT Act
• Hypertension (high blood pressure), added by the PACT Act

They carry the same presumption even where the regulation's own list has not caught up.

Timing rules

For most conditions on the list, there is no deadline: under 38 C.F.R. § 3.307(a)(6)(ii), the condition can show up at any time after service once it reaches a degree of 10 percent or more. Three are different. Chloracne, porphyria cutanea tarda, and early-onset peripheral neuropathy must have reached 10 percent or more within one year of your last exposure.

Where and when: the qualifying service

A few notes on the rows that trip people up:

• Blue Water Navy. Offshore service is defined in 38 U.S.C. § 1116A as within 12 nautical miles of a line drawn along the Vietnamese coast. Deck logs and ship histories are the usual proof.
• Korea. The statute (38 U.S.C. § 1116B) starts the DMZ window on September 1, 1967. You may still see April 1, 1968 in older material and in the regulation's text; the law now reads September 1, 1967.
• Thailand. Before the PACT Act, VA looked at whether you served near the base perimeter. The statute now covers any U.S. or Royal Thai base during the dates, regardless of where on the base you were or what your job was.
• C-123 aircraft. Air Force and Air Force Reserve members who regularly and repeatedly flew, maintained, or served aboard C-123s known to have sprayed herbicides during the Vietnam era are also presumed exposed, under 38 C.F.R. § 3.307(a)(6)(v).

Hypertension and heart disease are separate claims

Ischemic heart disease has been on the list for years. The regulation's note on it says it does not include hypertension, which is why hypertension was not presumptive until the PACT Act put it in the statute. They are now two separate presumptive conditions, rated under different codes. See the rating pages for ischemic heart disease and hypertension.

Conditions that are not on the list

A condition missing from the list can still be service-connected; it just doesn't get the shortcut. You would need a medical opinion that your exposure is at least as likely as not the cause, or a secondary route: peripheral neuropathy secondary to diabetes, for example, is a common and separate claim from early-onset peripheral neuropathy. See secondary service connection and the peripheral neuropathy rating page.

If you were denied before

Many veterans were denied for hypertension, Thailand service away from the perimeter, or Blue Water Navy service under the old rules. If that is you, file a supplemental claim (VA Form 20-0995) for the condition; the change in law is the reason to look again. The PACT Act guide covers the other changes it made.

The Service Exposure Finder checks your duty stations against these locations and dates. If you already have your records, you can upload them; the first 150 pages are read free.

Frequently asked questions

What are the Agent Orange presumptive conditions?

AL amyloidosis, bladder cancer, chloracne, chronic B-cell leukemias, type 2 diabetes, Hodgkin's disease, hypertension, hypothyroidism, ischemic heart disease, MGUS, multiple myeloma, non-Hodgkin's lymphoma, Parkinson's disease, Parkinsonism, early-onset peripheral neuropathy, porphyria cutanea tarda, prostate cancer, respiratory cancers (lung, bronchus, larynx, trachea), and most soft-tissue sarcomas.

Is high blood pressure an Agent Orange presumptive condition?

Yes. The PACT Act added hypertension to 38 U.S.C. § 1116 in 2022. Before that, VA treated it as separate from ischemic heart disease and did not presume it.

Does Thailand service count for Agent Orange?

Yes, service at any U.S. or Royal Thai base in Thailand from January 9, 1962 to June 30, 1976 counts, regardless of where on the base you were or what your job was. The old perimeter rule no longer limits it.

What are the Korean DMZ dates for Agent Orange?

Service in or near the Korean DMZ from September 1, 1967 to August 31, 1971, under 38 U.S.C. § 1116B.

Do I need a nexus letter for an Agent Orange condition?

Not for a condition on the list when your service matches a qualifying location and date. You need a current diagnosis and proof of the service. Conditions not on the list need a medical opinion.