Chronic Obstructive Pulmonary Disease
Open burn-pit smoke and aerosolized desert particulate exposure in the Southwest Asia theater (Iraq, Afghanistan, and the broader theater) as a cause of chronic respiratory disease; and, for the sinonasal conditions, the recognized secondary pathways to chronic rhinosinusitis under 38 C.F.R. § 3.310 (GERD/laryngopharyngeal reflux, septal deviation from in-service nasal trauma, and asthma/type 2 airway inflammation).
38 CFR diagnostic codes 6510, 6511, 6512, 6513, 6514, 6522, 6600, 6602, 6603, 6604
Peer-reviewed evidence (35)
The verified studies behind a Chronic Obstructive Pulmonary Disease claim — each links to its real PubMed or DOI record. These are sources our nexus drafts can draw from; none are invented.
- Barth SK, Dursa EK, Peterson MR, Schneiderman A. Prevalence of respiratory diseases among veterans of Operation Enduring Freedom and Operation Iraqi Freedom: results from the National Health Study for a New Generation of U.S. Veterans. Mil Med. 2014;179(3):241-5. PMID:24594456. doi:10.7205/MILMED-D-13-00338.
- Hill CJ, Meyer CD, McLean JE, Anderson DC, Hao Y, Lin FC, Kimple AJ, Capra GG. Burn Pit Exposure Is Associated With Increased Sinonasal Disease. J Occup Environ Med. 2022;64(8):629-634. PMID:35673272. doi:10.1097/JOM.0000000000002551.
- Waibel KH. Allergic rhinitis in the Middle East. Mil Med. 2005;170(12):1026-8. PMID:16491940. doi:10.7205/milmed.170.12.1026.
- National Academies of Sciences, Engineering, and Medicine; Committee on the Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. National Academies Press (Washington, DC); 2020. PMID:33030852. Available at: https://nap.nationalacademies.org/catalog/25837.
- Briggs EE, Schlosser NJ, Nguyen SA, Ryan MT, Duffy AN. Deployment as a Risk Factor of Rhinologic Disease: Systematic Review and Meta-Analysis. Mil Med. 2026;191(1-2):e95-e101. PMID:40574701. doi:10.1093/milmed/usaf302.
- Workman AD, Lee RJ, Cohen NA. Aerosolized Particulate Matter and Blunting of Ciliary Dynamic Responses: Implications for Veterans and Active Duty Military in Southwest Asia. Mil Med. 2024;189(7-8):e1537-e1543. PMID:38287786. doi:10.1093/milmed/usae007.
- Lee YK, Tsai M, Anderson L, Wang V, Yusin J. Chronic Nonallergic Rhinosinusitis Associated With Military Burn Pit Exposure. Cureus. 2025;17(5):e84584. PMID:40546639. doi:10.7759/cureus.84584.
- Almekdash MH, Han J, Guffey D, Christie IC, Helmer DA, Wu TD. Association of a Veterans Affairs Toxic Exposure Medical Evaluation with Symptom-related Care. Ann Am Thorac Soc. 2025;22(8):1176-1182. PMID:40245340. doi:10.1513/AnnalsATS.202408-835OC.
- Krefft SD, Zell-Baran LM. Deployment-Related Respiratory Disease: Where Are We? Semin Respir Crit Care Med. 2023;44(3):370-377. PMID:37068518. doi:10.1055/s-0043-1764407.
- Watanabe M, Kurai J, Tomita K, Sano H, Abe S, Saito R, Minato S, Igishi T, Burioka N, Sako T, Yasuda K, Mikami M, Kurita S, Tokuyasu H, Ueda Y, Konishi T, Yamasaki A, Aiba S, Oshimura M, Shimizu E. Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan. J Asthma. 2014;51(6):595-602. PMID:24628524. doi:10.3109/02770903.2014.903965.
- Goudie AS. Desert dust and human health disorders. Environ Int. 2014;63:101-13. PMID:24275707. doi:10.1016/j.envint.2013.10.011.
- Fussell JC, Kelly FJ. Mechanisms underlying the health effects of desert sand dust. Environ Int. 2021;157:106790. PMID:34333291. doi:10.1016/j.envint.2021.106790.
- Berman R, Rose CS, Downey GP, Day BJ, Chu HW. Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease. Chem Res Toxicol. 2021;34(12):2408-2423. PMID:34808040. doi:10.1021/acs.chemrestox.1c00090.
- Soy FK, Yazici H, Kulduk E, Dundar R, Tas Gulen S, Dogan S, Haberal Can I. The effects of dust storms on quality of life of allergic patients with or without asthma. Kulak Burun Bogaz Ihtis Derg. 2016;26(1):19-27. PMID:26794331. doi:10.5606/kbbihtisas.2016.56254.
- Goronfolah L. Aeroallergens, atopy and allergic rhinitis in the Middle East. Eur Ann Allergy Clin Immunol. 2016;48(1):5-21. PMID:26808447.
- Shin SH, Ye MK, Lee DW, Chae MH. Asian Sand Dust Particles Enhance the Development of Aspergillus fumigatus Biofilm on Nasal Epithelial Cells. Int J Mol Sci. 2022;23(6):3030. PMID:35328451. doi:10.3390/ijms23063030.
- Ichinose T, Hiyoshi K, Yoshida S, Takano H, Inoue K, Nishikawa M, Mori I, Kawazato H, Yasuda A, Shibamoto T. Asian sand dust aggravates allergic rhinitis in guinea pigs induced by Japanese cedar pollen. Inhal Toxicol. 2009;21(12):985-93. PMID:19552583. doi:10.1080/08958370802672883.
- Jung JH, Kang IG, Cha HE, Choe SH, Kim ST. Effect of Asian sand dust on mucin production in NCI-H292 cells and allergic murine model. Otolaryngol Head Neck Surg. 2012;146(6):887-94. PMID:22402586. doi:10.1177/0194599812439011.
- Dursa EK, Tadesse BE, Carter CE, Culpepper WJ, Schneiderman AI, Rumm PD. Respiratory illness among Gulf War and Gulf War era veterans who use the Department of Veterans Affairs for healthcare. Am J Ind Med. 2020;63(11):980-987. PMID:32851693. doi:10.1002/ajim.23172.
- Maccarone J, Redlich CA, Timmons A, Korpak AM, Smith NL, Nakayama KS, Baird CP, Ciminera P. Sinusitis and rhinitis among US veterans deployed to Southwest Asia and Afghanistan after September 11, 2001. J Allergy Clin Immunol Glob. 2025;4(1):100367. PMID:39659739. doi:10.1016/j.jacig.2024.100367.
- Elam T, Raiculescu S, Biswal S, Zhang Z, Orestes M, Ramanathan M. Air Pollution Exposure and the Development of Chronic Rhinosinusitis in the Active Duty Population. Mil Med. 2023;188(7-8):e1957-64. PMID:35015888. doi:10.1093/milmed/usab535.
- Autio TJ, Tapiainen T, Koskenkorva T, Narkio M, Lappalainen M, Nikkari S, Hemmila H, Koskela KA, Koskela M, Koivunen P, Alho OP. The role of microbes in the pathogenesis of acute rhinosinusitis in young adults. Laryngoscope. 2015;125(1):E1-7. PMID:25093843. doi:10.1002/lary.24862.
- Autio TJ, Koskenkorva T, Narkio M, Leino TK, Koivunen P, Alho OP. Imaging follow-up study of acute rhinosinusitis. Laryngoscope. 2016;126(9):1965-70. PMID:27557439. doi:10.1002/lary.25843.
- Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Kumar KA, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S1-S39. PMID:25832968. doi:10.1177/0194599815572097.
- Keating MK, Phillips JC, Phillips J. Chronic Rhinosinusitis. Am Fam Physician. 2023;108(4):370-377. PMID:37843944.
- Lechien JR, Saussez S, Hopkins C. Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review. Clin Otolaryngol. 2023;48(4):501-514. PMID:36895147. doi:10.1111/coa.14047.
- Hanna BC, Wormald PJ. Gastroesophageal reflux and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2012;20(1):15-18. PMID:22157165. doi:10.1097/MOO.0b013e32834e8f11.
- Nikkerdar N, Karimi A, Bazmayoon F, Golshah A. Comparison of the Type and Severity of Nasal Septal Deviation between Chronic Rhinosinusitis Patients Undergoing Functional Endoscopic Sinus Surgery and Controls. Int J Dent. 2022;2022:2925279. PMID:35510085. doi:10.1155/2022/2925279.
- Malpani SN, Deshmukh P. Deviated Nasal Septum a Risk Factor for the Occurrence of Chronic Rhinosinusitis. Cureus. 2022;14(10):e30261. PMID:36381736. doi:10.7759/cureus.30261.
- Laidlaw TM, Mullol J, Woessner KM, Amin N, Mannent LP. Chronic Rhinosinusitis with Nasal Polyps and Asthma. J Allergy Clin Immunol Pract. 2021;9(3):1133-1141. PMID:33065369. doi:10.1016/j.jaip.2020.09.063.
- Rosati MG, Peters AT. Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis. Am J Rhinol Allergy. 2016;30(1):44-47. PMID:26867529. doi:10.2500/ajra.2016.30.4252.
- Khan AH, Gouia I, Kamat S, Johnson R, Small M, Siddall J. Prevalence and Severity Distribution of Type 2 Inflammation-Related Comorbidities Among Patients with Asthma, Chronic Rhinosinusitis with Nasal Polyps, and Atopic Dermatitis. Lung. 2023;201(1):57-63. PMID:36808551. doi:10.1007/s00408-023-00603-z.
- Kim SY, Park B, Lim H, Kim M, Kong IG, Choi HG. Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case-control study using a national sample cohort. Int Forum Allergy Rhinol. 2019;9(4):357-362. PMID:30548214. doi:10.1002/alr.22259.
- Wu C, Zhang Z, Yan X, Wang L, Yu L, Jiang Y. Causal Relationship Between Gastroesophageal Reflux Disease and the Risk of Chronic Rhinosinusitis: Insights from Multivariable and Mediation Mendelian Randomization Analysis. Ear Nose Throat J. 2024;. PMID:39363451. doi:10.1177/01455613241286611.
- Stevens WW, Peters AT. Immunodeficiency in chronic sinusitis: recognition and treatment. Am J Rhinol Allergy. 2015;29(2):115-118. PMID:25785751. doi:10.2500/ajra.2015.29.4144.
Controlling law
The CFR sections and cases the theories relevant to this condition rest on — the legal standard raters evaluate against, never a prediction about any claim.
Direct (§ 3.303)
Regulation
38 C.F.R. § 3.303
Direct service connection — a current disability linked to service. (Continuity of symptomatology under § 3.303(b) is limited by case law to the § 3.309(a) chronic diseases — Walker.)
Case law
Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004)
The three-element test: current disability, in-service event, and a nexus between them.
Holton v. Shinseki, 557 F.3d 1363 (Fed. Cir. 2009)
Federal Circuit restatement of the same three direct-service-connection elements.
Caluza v. Brown, 7 Vet. App. 498 (1995)
The evidentiary framework a rater weighs each element against.
Walker v. Shinseki, 708 F.3d 1331 (Fed. Cir. 2013)
Continuity of symptomatology (§ 3.303(b)) is available ONLY for a chronic disease listed in § 3.309(a); any other condition must use the medical-nexus pathway.
Davidson v. Shinseki, 581 F.3d 1313 (Fed. Cir. 2009)
A categorical 'a medical opinion is always required for nexus' is legal error — competent lay evidence can suffice.
Jandreau v. Nicholson, 492 F.3d 1372 (Fed. Cir. 2007); Layno v. Brown, 6 Vet. App. 465 (1994)
A veteran is competent to report symptoms they personally observe (Layno), and lay evidence can even establish a simple diagnosis in the right case (Jandreau).
McLendon v. Nicholson, 20 Vet. App. 79 (2006)
A LOW threshold — evidence that merely indicates a nexus MAY exist obligates VA to provide a C&P exam.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Secondary (§ 3.310)
Regulation
38 C.F.R. § 3.310(a)
A condition proximately caused by a service-connected condition (or by the treatment it requires).
38 C.F.R. § 3.310(b)
A condition worsened beyond its natural progression by a service-connected condition.
Case law
Wallin v. West, 11 Vet. App. 509 (1998)
The three secondary elements: a current disability, a service-connected disability, and medical-nexus evidence linking them.
Allen v. Brown, 7 Vet. App. 439 (1995)
Secondary aggravation is compensable for the degree of worsening over the pre-aggravation baseline.
El-Amin v. Shinseki, 26 Vet. App. 136 (2013)
An opinion addressing only causation is inadequate where aggravation is also raised — the letter must speak to both prongs.
Spicer v. McDonough, 61 F.4th 1360 (Fed. Cir. 2023)
Expanded what qualifies (severity-worsening and treatment-based theories suffice; a § 3.310(b) baseline/permanence objection cannot defeat a but-for severity theory). Not a heightened standard.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Aggravation (§ 3.306)
Regulation
38 C.F.R. § 3.306 (38 U.S.C. § 1153)
DIRECT aggravation: a pre-existing condition NOTED AT ENTRY that increased in disability during service — unless the increase is due to the natural progress of the disease. An in-service increase raises a PRESUMPTION of aggravation VA must rebut.
38 C.F.R. § 3.310(b)
SECONDARY aggravation (a distinct branch): a non-service-connected condition worsened by an already service-connected condition — see Allen.
Case law
Wagner v. Principi, 370 F.3d 1089 (Fed. Cir. 2004)
If the condition was NOT noted at entry, the veteran is presumed sound; VA must rebut BOTH pre-existence and lack of aggravation by clear and unmistakable EVIDENCE (not the CUE error doctrine). If VA fails, the claim proceeds as ordinary DIRECT service connection — not as an aggravation claim.
Horn v. Shinseki, 25 Vet. App. 231 (2012)
That rebuttal burden never shifts back to the veteran — VA must rely on affirmative evidence of no aggravation.
Hunt v. Derwinski, 1 Vet. App. 292 (1991); Davis v. Principi, 276 F.3d 1341 (Fed. Cir. 2002)
Temporary flare-ups are not aggravation — the UNDERLYING condition (not just symptoms) must have worsened.
Allen v. Brown, 7 Vet. App. 439 (1995)
Compensation is for the measurable degree of worsening over the established baseline.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
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