High Blood Pressure
Herbicide exposure and hypertension (National Academies Update 11: sufficient evidence of an association, the basis for the PACT Act presumptive) and open-burn-pit deployment, plus combat exposure and injury severity, occupational job strain, rotating shift work and noise as direct exposures — with the PTSD/combat-stress and obstructive-sleep-apnea pathways supporting secondary service connection.
38 CFR diagnostic code 7101
Peer-reviewed evidence (34)
The verified studies behind a High Blood Pressure claim — each links to its real PubMed or DOI record. These are sources our nexus drafts can draw from; none are invented.
- National Academies of Sciences, Engineering, and Medicine; Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eleventh Biennial Update). Veterans and Agent Orange: Update 11 (2018). The National Academies Press, Washington, DC; 2018. doi:10.17226/25137. Available at: https://doi.org/10.17226/25137.
- Savitz DA, Woskie SR, Bello A, Gaither R, Gasper J, Jiang L, Rennix C, Wellenius GA, Trivedi AN. Deployment to Military Bases With Open Burn Pits and Respiratory and Cardiovascular Disease. JAMA Netw Open. 2024;7(4):e247629. PMID:38662371. doi:10.1001/jamanetworkopen.2024.7629.
- Cypel YS, Kress AM, Eber SM, Schneiderman AI, Davey VJ. Herbicide Exposure, Vietnam Service, and Hypertension Risk in Army Chemical Corps Veterans. J Occup Environ Med. 2016;58(11):1127-1136. PMID:27820763. doi:10.1097/JOM.0000000000000876.
- Kang HK, Dalager NA, Needham LL, Patterson DG Jr, Lees PS, Yates K, Matanoski GM. Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. Am J Ind Med. 2006;49(11):875-84. PMID:17006952. doi:10.1002/ajim.20385.
- Howard JT, Stewart IJ, Kolaja CA, Sosnov JA, Rull RP, Torres I, Janak JC, Walker LE, Trone DW, Armenta RF. Hypertension in military veterans is associated with combat exposure and combat injury. J Hypertens. 2020;38(7):1293-1301. PMID:31990903. doi:10.1097/HJH.0000000000002364.
- Granado NS, Smith TC, Swanson GM, Harris RB, Shahar E, Smith B, Boyko EJ, Wells TS, Ryan MA. Newly reported hypertension after military combat deployment in a large population-based study. Hypertension. 2009;54(5):966-73. PMID:19752293. doi:10.1161/HYPERTENSIONAHA.109.132555.
- Howard JT, Sosnov JA, Janak JC, Gundlapalli AV, Pettey WB, Walker LE, Stewart IJ. Associations of Initial Injury Severity and Posttraumatic Stress Disorder Diagnoses With Long-Term Hypertension Risk After Combat Injury. Hypertension. 2018;71(5):824-832. PMID:29555664. doi:10.1161/HYPERTENSIONAHA.117.10496.
- Babu GR, Jotheeswaran AT, Mahapatra T, Mahapatra S, Kumar A Sr, Detels R, Pearce N. Is hypertension associated with job strain? A meta-analysis of observational studies. Occup Environ Med. 2014;71(3):220-7. PMID:24142979. doi:10.1136/oemed-2013-101396.
- Landsbergis PA, Dobson M, Koutsouras G, Schnall P. Job strain and ambulatory blood pressure: a meta-analysis and systematic review. Am J Public Health. 2013;103(3):e61-71. PMID:23327240. doi:10.2105/AJPH.2012.301153.
- Bolm-Audorff U, Hegewald J, Pretzsch A, Freiberg A, Nienhaus A, Seidler A. Occupational Noise and Hypertension Risk: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020;17(17):6281. PMID:32872306. doi:10.3390/ijerph17176281.
- Manohar S, Thongprayoon C, Cheungpasitporn W, Mao MA, Herrmann SM. Associations of rotational shift work and night shift status with hypertension: a systematic review and meta-analysis. J Hypertens. 2017;35(10):1929-1937. PMID:28650914. doi:10.1097/HJH.0000000000001442.
- Smoley BA, Smith NL, Runkle GP. Hypertension in a population of active duty service members. J Am Board Fam Med. 2008;21(6):504-11. PMID:18988717. doi:10.3122/jabfm.2008.06.070182.
- van Kempen E, Babisch W. The quantitative relationship between road traffic noise and hypertension: a meta-analysis. J Hypertens. 2012;30(6):1075-86. PMID:22473017. doi:10.1097/HJH.0b013e328352ac54.
- Wang Q, Xi B, Liu M, Zhang Y, Fu M. Short sleep duration is associated with hypertension risk among adults: a systematic review and meta-analysis. Hypertens Res. 2012;35(10):1012-8. PMID:22763475. doi:10.1038/hr.2012.91.
- Burg MM, Brandt C, Buta E, Schwartz J, Bathulapalli H, Dziura J, Edmondson DE, Haskell S. Risk for incident hypertension associated with posttraumatic stress disorder in military veterans and the effect of posttraumatic stress disorder treatment. Psychosom Med. 2017;79(2):181-188. PMID:27490852. doi:10.1097/PSY.0000000000000376.
- Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378-84. PMID:10805822. doi:10.1056/NEJM200005113421901.
- Marin JM, Agusti A, Villar I, Forner M, Nieto D, Carrizo SJ, Barbe F, Vicente E, Wei Y. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307(20):2169-76. PMID:22618924. doi:10.1001/jama.2012.3418.
- Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, Dempsey J. Sleep apnea and hypertension. A population-based study. Ann Intern Med. 1994;120(5):382-8. PMID:8304655. doi:10.7326/0003-4819-120-5-199403010-00005.
- Turnbull CD, Sen D, Kohler M, Petousi N, Stradling JR. Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial. Am J Respir Crit Care Med. 2019;199(2):211-219. PMID:30025470. doi:10.1164/rccm.201802-0240OC.
- Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest. 1995;96(4):1897-904. PMID:7560081. doi:10.1172/JCI118235.
- Prabhakar NR, Kumar GK. Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia. Respir Physiol Neurobiol. 2010;174(1-2):156-61. PMID:20804865. doi:10.1016/j.resp.2010.08.021.
- Shang W, Zhang Y, Liu L, Chen F, Wang G, Han D. Benefits of continuous positive airway pressure on blood pressure in patients with hypertension and obstructive sleep apnea: a meta-analysis. Hypertens Res. 2022;45(11):1802-1813. PMID:35701490. doi:10.1038/s41440-022-00954-9.
- Haentjens P, Van Meerhaeghe A, Moscariello A, De Weerdt S, Poppe K, Dupont A, Velkeniers B. The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials. Arch Intern Med. 2007;167(8):757-64. PMID:17452537. doi:10.1001/archinte.167.8.757.
- Schein ASO, Kerkhoff AC, Coronel CC, Plentz RDM, Sbruzzi G. Continuous positive airway pressure reduces blood pressure in patients with obstructive sleep apnea; a systematic review and meta-analysis with 1000 patients. J Hypertens. 2014;32(9):1762-73. PMID:24979300. doi:10.1097/HJH.0000000000000250.
- Martinez-Garcia MA, Capote F, Campos-Rodriguez F, Lloberes P, Diaz de Atauri MJ, Somoza M, Masa JF, Gonzalez M, Sacristan L. Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA. 2013;310(22):2407-15. PMID:24327037. doi:10.1001/jama.2013.281250.
- Iftikhar IH, Valentine CW, Bittencourt LRA, Cohen DL, Fedson AC, Gislason T, Penzel T, Phillips CL, Yu-sheng L. Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens. 2014;32(12):2341-50; discussion 2350. PMID:25243523. doi:10.1097/HJH.0000000000000372.
- Sumner JA, Kubzansky LD, Roberts AL, Gilsanz P, Chen Q, Winning A, Forman JP, Rimm EB, Koenen KC. Post-traumatic stress disorder symptoms and risk of hypertension over 22 years in a large cohort of younger and middle-aged women. Psychol Med. 2016;46(15):3105-3116. PMID:27534802.
- Bourassa KJ, Anderson L, Brown JC, Dennis PA, Garrett ME, Ashley-Koch AE, Beckham JC, Kimbrel NA. Trauma, posttraumatic stress disorder, and incident chronic disease. Ann Behav Med. 2025;59(1):kaaf095. PMID:41350112. doi:10.1093/abm/kaaf095.
- Sumner JA, Kubzansky LD, Roberts AL, Chen Q, Rimm EB, Koenen KC. Not all posttraumatic stress disorder symptoms are equal: fear, dysphoria, and risk of developing hypertension in trauma-exposed women. Psychol Med. 2020;50(1):38-47. PMID:30606272. doi:10.1017/S0033291718003914.
- Gaffey AE, Redeker NS, Rosman L, Mullington JM, Brandt CA, Haskell SG, Burg MM. The role of insomnia in the association between posttraumatic stress disorder and hypertension. J Hypertens. 2020;38(4):641-648. PMID:31725076. doi:10.1097/HJH.0000000000002311.
- Wingenfeld K, Whooley MA, Neylan TC, Otte C, Cohen BE. Effect of current and lifetime posttraumatic stress disorder on 24-h urinary catecholamines and cortisol: results from the Mind Your Heart Study. Psychoneuroendocrinology. 2015;52:83-91. PMID:25459895. doi:10.1016/j.psyneuen.2014.10.023.
- Martin ZT, Shah AJ, Ko YA, Sheikh SA, Daaboul O, Haddad G, Goldberg J, Smith NL, Lewis TT, Quyyumi AA, Bremner JD, Vaccarino V. Exaggerated Peripheral and Systemic Vasoconstriction During Trauma Recall in Posttraumatic Stress Disorder: A Co-Twin Control Study. Biol Psychiatry. 2024;96(4):278-286. PMID:38142719. doi:10.1016/j.biopsych.2023.12.014.
- Bartoli F, Carrà G, Crocamo C, Carretta D, Clerici M. Metabolic syndrome in people suffering from posttraumatic stress disorder: a systematic review and meta-analysis. Metab Syndr Relat Disord. 2013;11(5):301-8. PMID:23758060. doi:10.1089/met.2013.0010.
- Ulmer CS, Calhoun PS, Bosworth HB, Dennis MF, Beckham JC. Nocturnal blood pressure non-dipping, posttraumatic stress disorder, and sleep quality in women. Behav Med. 2013;39(4):111-21. PMID:24236808. doi:10.1080/08964289.2013.813434.
Controlling law
The CFR sections and cases the theories relevant to this condition rest on — the legal standard raters evaluate against, never a prediction about any claim.
Direct (§ 3.303)
Regulation
38 C.F.R. § 3.303
Direct service connection — a current disability linked to service. (Continuity of symptomatology under § 3.303(b) is limited by case law to the § 3.309(a) chronic diseases — Walker.)
Case law
Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004)
The three-element test: current disability, in-service event, and a nexus between them.
Holton v. Shinseki, 557 F.3d 1363 (Fed. Cir. 2009)
Federal Circuit restatement of the same three direct-service-connection elements.
Caluza v. Brown, 7 Vet. App. 498 (1995)
The evidentiary framework a rater weighs each element against.
Walker v. Shinseki, 708 F.3d 1331 (Fed. Cir. 2013)
Continuity of symptomatology (§ 3.303(b)) is available ONLY for a chronic disease listed in § 3.309(a); any other condition must use the medical-nexus pathway.
Davidson v. Shinseki, 581 F.3d 1313 (Fed. Cir. 2009)
A categorical 'a medical opinion is always required for nexus' is legal error — competent lay evidence can suffice.
Jandreau v. Nicholson, 492 F.3d 1372 (Fed. Cir. 2007); Layno v. Brown, 6 Vet. App. 465 (1994)
A veteran is competent to report symptoms they personally observe (Layno), and lay evidence can even establish a simple diagnosis in the right case (Jandreau).
McLendon v. Nicholson, 20 Vet. App. 79 (2006)
A LOW threshold — evidence that merely indicates a nexus MAY exist obligates VA to provide a C&P exam.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Secondary (§ 3.310)
Regulation
38 C.F.R. § 3.310(a)
A condition proximately caused by a service-connected condition (or by the treatment it requires).
38 C.F.R. § 3.310(b)
A condition worsened beyond its natural progression by a service-connected condition.
Case law
Wallin v. West, 11 Vet. App. 509 (1998)
The three secondary elements: a current disability, a service-connected disability, and medical-nexus evidence linking them.
Allen v. Brown, 7 Vet. App. 439 (1995)
Secondary aggravation is compensable for the degree of worsening over the pre-aggravation baseline.
El-Amin v. Shinseki, 26 Vet. App. 136 (2013)
An opinion addressing only causation is inadequate where aggravation is also raised — the letter must speak to both prongs.
Spicer v. McDonough, 61 F.4th 1360 (Fed. Cir. 2023)
Expanded what qualifies (severity-worsening and treatment-based theories suffice; a § 3.310(b) baseline/permanence objection cannot defeat a but-for severity theory). Not a heightened standard.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Aggravation (§ 3.306)
Regulation
38 C.F.R. § 3.306 (38 U.S.C. § 1153)
DIRECT aggravation: a pre-existing condition NOTED AT ENTRY that increased in disability during service — unless the increase is due to the natural progress of the disease. An in-service increase raises a PRESUMPTION of aggravation VA must rebut.
38 C.F.R. § 3.310(b)
SECONDARY aggravation (a distinct branch): a non-service-connected condition worsened by an already service-connected condition — see Allen.
Case law
Wagner v. Principi, 370 F.3d 1089 (Fed. Cir. 2004)
If the condition was NOT noted at entry, the veteran is presumed sound; VA must rebut BOTH pre-existence and lack of aggravation by clear and unmistakable EVIDENCE (not the CUE error doctrine). If VA fails, the claim proceeds as ordinary DIRECT service connection — not as an aggravation claim.
Horn v. Shinseki, 25 Vet. App. 231 (2012)
That rebuttal burden never shifts back to the veteran — VA must rely on affirmative evidence of no aggravation.
Hunt v. Derwinski, 1 Vet. App. 292 (1991); Davis v. Principi, 276 F.3d 1341 (Fed. Cir. 2002)
Temporary flare-ups are not aggravation — the UNDERLYING condition (not just symptoms) must have worsened.
Allen v. Brown, 7 Vet. App. 439 (1995)
Compensation is for the measurable degree of worsening over the established baseline.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Presumptive (§ 3.307–3.309)
Regulation
38 C.F.R. §§ 3.307, 3.309
Presumptive service connection — the link is presumed by law for qualifying service/exposure; no nexus opinion is needed.
38 C.F.R. §§ 3.317, 3.320
Gulf War undiagnosed / chronic multisymptom illness (§ 3.317), and burn-pit / particulate-matter presumptions (§ 3.320).
38 U.S.C. §§ 1116, 1117, 1119, 1120
Herbicide (incl. PACT-added hypertension), Gulf War illness, the presumption of EXPOSURE for covered veterans, and burn-pit disease presumptions.
Case law
Combee v. Brown, 34 F.3d 1039 (Fed. Cir. 1994)
The presumptive path is NOT exclusive — a veteran may ALSO prove direct causation the ordinary way.
Gutierrez v. Principi, 19 Vet. App. 1 (2004)
A § 3.317 Gulf War claim needs no nexus evidence — lay-observable symptoms suffice.
Procopio v. Wilkie, 913 F.3d 1371 (Fed. Cir. 2019) (en banc)
Blue Water Navy veterans are covered by the herbicide presumption.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
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