Post-traumatic Headache
Deployment-related traumatic brain injury and post-traumatic headache/migraine in service members and veterans.
38 CFR diagnostic code 8100
Peer-reviewed evidence (40)
The verified studies behind a Post-traumatic Headache claim — each links to its real PubMed or DOI record. These are sources our nexus drafts can draw from; none are invented.
- Jankosky CJ, Hooper TI, Granado NS, Scher A, Gackstetter GD, Boyko EJ, Smith TC; Millennium Cohort Study Team. Headache disorders in the millennium cohort: epidemiology and relations with combat deployment. Headache. 2011;51(7):1098-1111. PMID:21675968. doi:10.1111/j.1526-4610.2011.01914.x.
- Theeler BJ, Mercer R, Erickson JC. Prevalence and impact of migraine among US Army soldiers deployed in support of Operation Iraqi Freedom. Headache. 2008;48(6):876-882. PMID:18549370. doi:10.1111/j.1526-4610.2008.01159.x.
- Helseth EK, Erickson JC. The prevalence and impact of migraine on US Military officer trainees. Headache. 2008;48(6):883-889. PMID:18005047. doi:10.1111/j.1526-4610.2007.00962.x.
- Theeler BJ, Flynn FG, Erickson JC. Headaches after concussion in US soldiers returning from Iraq or Afghanistan. Headache. 2010;50(8):1262-1272. PMID:20553333. doi:10.1111/j.1526-4610.2010.01700.x.
- Theeler BJ, Flynn FG, Erickson JC. Chronic daily headache in U.S. soldiers after concussion. Headache. 2012;52(5):732-738. PMID:22404747. doi:10.1111/j.1526-4610.2012.02112.x.
- Theeler BJ, Erickson JC. Mild head trauma and chronic headaches in returning US soldiers. Headache. 2009;49(4):529-534. PMID:19220499. doi:10.1111/j.1526-4610.2009.01345.x.
- Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008;358(5):453-463. PMID:18234750. doi:10.1056/NEJMoa072972.
- Theeler B, Lucas S, Riechers RG 2nd, Ruff RL. Post-traumatic headaches in civilians and military personnel: a comparative, clinical review. Headache. 2013;53(6):881-900. PMID:23721236. doi:10.1111/head.12123.
- Theeler BJ, Erickson JC. Posttraumatic headache in military personnel and veterans of the iraq and afghanistan conflicts. Curr Treat Options Neurol. 2012;14(1):36-49. PMID:22116663. doi:10.1007/s11940-011-0157-2.
- Theeler BJ, Kenney K, Prokhorenko OA, Fideli US, Campbell W, Erickson JC. Headache triggers in the US military. Headache. 2010;50(5):790-794. PMID:19925623. doi:10.1111/j.1526-4610.2009.01571.x.
- Houle TT, Butschek RA, Turner DP, Smitherman TA, Rains JC, Penzien DB. Stress and sleep duration predict headache severity in chronic headache sufferers. Pain. 2012;153(12):2432-2440. PMID:23073072. doi:10.1016/j.pain.2012.08.014.
- Wilk JE, Herrell RK, Wynn GH, Riviere LA, Hoge CW. Mild traumatic brain injury (concussion), posttraumatic stress disorder, and depression in U.S. soldiers involved in combat deployments: association with postdeployment symptoms. Psychosom Med. 2012;74(3):249-257. PMID:22366583. doi:10.1097/PSY.0b013e318244c604.
- Riechers RG 2nd, Walker MF, Ruff RL. Post-traumatic headaches. Handb Clin Neurol. 2015;128:567-78. PMID:25701908. doi:10.1016/B978-0-444-63521-1.00036-4.
- Neely ET, Midgette LA, Scher AI. Clinical review and epidemiology of headache disorders in US service members: with emphasis on post-traumatic headache. Headache. 2009;49(7):1089-96. PMID:19583598. doi:10.1111/j.1526-4610.2009.001460.x.
- Gasperi M, Schuster NM, Franklin B, Nievergelt CM, Stein MB, Afari N. Migraine Prevalence, Environmental Risk, and Comorbidities in Men and Women Veterans. JAMA Netw Open. 2024;7(3):e242299. PMID:38483390. doi:10.1001/jamanetworkopen.2024.2299.
- Couch JR, Stewart KE. Headache Prevalence at 4-11 Years After Deployment-Related Traumatic Brain Injury in Veterans of Iraq and Afghanistan Wars and Comparison to Controls: A Matched Case-Controlled Study. Headache. 2016;56(6):1004-21. PMID:27237921. doi:10.1111/head.12837.
- Coffman C, Reyes D, Hess MC, Giakas AM, Thiam M, Sico JJ, Seng E, Renthal W. Relationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review. Neurology. 2022;99(2):e187-e198. PMID:35470141. doi:10.1212/WNL.0000000000200518.
- Becker WJ. Cervicogenic headache: evidence that the neck is a pain generator. Headache. 2010;50(4):699-705. PMID:20456156. doi:10.1111/j.1526-4610.2010.01648.x.
- Nitsche L, Helbach J, Stubenrauch S, Lakeberg M, Bantel C, Hoffmann F. The association between posttraumatic stress disorder and migraine: A systematic review. Headache. 2026;66(4):963-975. PMID:41705319. doi:10.1111/head.70058.
- Smitherman TA, Kolivas ED. Trauma exposure versus posttraumatic stress disorder: relative associations with migraine. Headache. 2013;53(5):775-86. PMID:23464926. doi:10.1111/head.12063.
- Afari N, Harder LH, Madra NJ, Heppner PS, Moeller-Bertram T, King C, Baker DG. PTSD, combat injury, and headache in Veterans Returning from Iraq/Afghanistan. Headache. 2009;49(9):1267-76. PMID:19788469. doi:10.1111/j.1526-4610.2009.01517.x.
- Arcaya MC, Lowe SR, Asad AL, Subramanian SV, Waters MC, Rhodes J. Association of posttraumatic stress disorder symptoms with migraine and headache after a natural disaster. Health Psychol. 2017;36(5):411-418. PMID:27929328. doi:10.1037/hea0000433.
- Peterlin BL, Tietjen GE, Brandes JL, Rubin SM, Drexler E, Lidicker JR, Meng S. Posttraumatic stress disorder in migraine. Headache. 2009;49(4):541-51. PMID:19245387. doi:10.1111/j.1526-4610.2009.01368.x.
- Minen MT, Begasse De Dhaem O, Kroon Van Diest A, Powers S, Schwedt TJ, Lipton R, Silbersweig D. Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry. 2016;87(7):741-9. PMID:26733600. doi:10.1136/jnnp-2015-312233.
- Peterlin BL, Nijjar SS, Tietjen GE. Post-traumatic stress disorder and migraine: epidemiology, sex differences, and potential mechanisms. Headache. 2011;51(6):860-8. PMID:21592096. doi:10.1111/j.1526-4610.2011.01907.x.
- Stubberud A, Buse DC, Kristoffersen ES, Linde M, Tronvik E. Is there a causal relationship between stress and migraine? Current evidence and implications for management. J Headache Pain. 2021;22(1):155. PMID:34930118. doi:10.1186/s10194-021-01369-6.
- Sauro KM, Becker WJ. The stress and migraine interaction. Headache. 2009;49(9):1378-86. PMID:19619238. doi:10.1111/j.1526-4610.2009.01486.x.
- Maleki N, Becerra L, Borsook D. Migraine: maladaptive brain responses to stress. Headache. 2012;52(Suppl 2):102-6. PMID:23030541. doi:10.1111/j.1526-4610.2012.02241.x.
- Suzuki K, Suzuki S, Shiina T, Kobayashi S, Hirata K. Central Sensitization in Migraine: A Narrative Review. J Pain Res. 2022;15:2673-2682. PMID:36101891. doi:10.2147/JPR.S329280.
- McGeary DD, Resick PA, Penzien DB, McGeary CA, Houle TT, Eapen BC, Jaramillo CA, Nabity PS, Reed DE 2nd. Cognitive Behavioral Therapy for Veterans With Comorbid Posttraumatic Headache and Posttraumatic Stress Disorder Symptoms: A Randomized Clinical Trial. JAMA Neurol. 2022;79(8):746-757. PMID:35759281. doi:10.1001/jamaneurol.2022.1567.
- Ashina H, Eigenbrodt AK, Seifert T, Sinclair AJ, Scher AI, Schytz HW, Lee MJ, De Icco R, Finkel AG, Ashina M. Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment. Lancet Neurol. 2021;20(6):460-469. PMID:34022171. doi:10.1016/S1474-4422(21)00094-6.
- Ashina H, Dodick DW, Barber J, Temkin NR, Chong CD, Adler JS, Shubin Stein K, Schwedt TJ, Manley GT. Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study. Mayo Clin Proc. 2023;98(10):1515-1526. PMID:37480909. doi:10.1016/j.mayocp.2023.02.026.
- Chen MH, Sung YF, Chien WC, Chung CH, Chen JW. Risk of Migraine after Traumatic Brain Injury and Effects of Injury Management Levels and Treatment Modalities: A Nationwide Population-Based Cohort Study in Taiwan. J Clin Med. 2023;12(4):1530. PMID:36836064. doi:10.3390/jcm12041530.
- Nabity PS, Jaramillo CA, Resick PA, McGeary CA, Eapen BC, Straud CL, Hale WJ, Houle TT, Litz BT, Mintz J, Penzien DB, Young-McCaughan S, Keane TM, Peterson AL, McGeary DD. Persistent posttraumatic headaches and functioning in veterans: Injury type can matter. Headache. 2021;61(9):1334-1341. PMID:34570899. doi:10.1111/head.14210.
- Howard L, Dumkrieger G, Chong CD, Ross K, Berisha V, Schwedt TJ. Symptoms of Autonomic Dysfunction Among Those With Persistent Posttraumatic Headache Attributed to Mild Traumatic Brain Injury: A Comparison to Migraine and Healthy Controls. Headache. 2018;58(9):1397-1407. PMID:30156267. doi:10.1111/head.13396.
- Kamins J, Charles A. Posttraumatic Headache: Basic Mechanisms and Therapeutic Targets. Headache. 2018;58(6):811-826. PMID:29757458. doi:10.1111/head.13312.
- Chong CD, Nikolova J, Dumkrieger GM. Migraine and Posttraumatic Headache: Similarities and Differences in Brain Network Connectivity. Semin Neurol. 2022;42(4):441-448. PMID:36323298. doi:10.1055/s-0042-1757929.
- Kamins JL, Karimi R, Hoffman A, Prins ML, Giza CC. Biomarkers and Endophenotypes of Post-traumatic Headaches. Curr Pain Headache Rep. 2024;28(12):1185-1193. PMID:39136870. doi:10.1007/s11916-024-01255-1.
- Williams KA, Lawson RM, Perurena OH, Coppin JD. Management of Chronic Migraine and Occipital Neuralgia in Post 9/11 Combat Veterans. Mil Med. 2019;184(7-8):e207-e211. PMID:30690565. doi:10.1093/milmed/usy405.
- Capi M, Pomes LM, Andolina G, Curto M, Martelletti P, Lionetto L. Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons. Int J Environ Res Public Health. 2020;17(7):2585. PMID:32283843. doi:10.3390/ijerph17072585.
Controlling law
The CFR sections and cases the theories relevant to this condition rest on — the legal standard raters evaluate against, never a prediction about any claim.
Direct (§ 3.303)
Regulation
38 C.F.R. § 3.303
Direct service connection — a current disability linked to service. (Continuity of symptomatology under § 3.303(b) is limited by case law to the § 3.309(a) chronic diseases — Walker.)
Case law
Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004)
The three-element test: current disability, in-service event, and a nexus between them.
Holton v. Shinseki, 557 F.3d 1363 (Fed. Cir. 2009)
Federal Circuit restatement of the same three direct-service-connection elements.
Caluza v. Brown, 7 Vet. App. 498 (1995)
The evidentiary framework a rater weighs each element against.
Walker v. Shinseki, 708 F.3d 1331 (Fed. Cir. 2013)
Continuity of symptomatology (§ 3.303(b)) is available ONLY for a chronic disease listed in § 3.309(a); any other condition must use the medical-nexus pathway.
Davidson v. Shinseki, 581 F.3d 1313 (Fed. Cir. 2009)
A categorical 'a medical opinion is always required for nexus' is legal error — competent lay evidence can suffice.
Jandreau v. Nicholson, 492 F.3d 1372 (Fed. Cir. 2007); Layno v. Brown, 6 Vet. App. 465 (1994)
A veteran is competent to report symptoms they personally observe (Layno), and lay evidence can even establish a simple diagnosis in the right case (Jandreau).
McLendon v. Nicholson, 20 Vet. App. 79 (2006)
A LOW threshold — evidence that merely indicates a nexus MAY exist obligates VA to provide a C&P exam.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Secondary (§ 3.310)
Regulation
38 C.F.R. § 3.310(a)
A condition proximately caused by a service-connected condition (or by the treatment it requires).
38 C.F.R. § 3.310(b)
A condition worsened beyond its natural progression by a service-connected condition.
Case law
Wallin v. West, 11 Vet. App. 509 (1998)
The three secondary elements: a current disability, a service-connected disability, and medical-nexus evidence linking them.
Allen v. Brown, 7 Vet. App. 439 (1995)
Secondary aggravation is compensable for the degree of worsening over the pre-aggravation baseline.
El-Amin v. Shinseki, 26 Vet. App. 136 (2013)
An opinion addressing only causation is inadequate where aggravation is also raised — the letter must speak to both prongs.
Spicer v. McDonough, 61 F.4th 1360 (Fed. Cir. 2023)
Expanded what qualifies (severity-worsening and treatment-based theories suffice; a § 3.310(b) baseline/permanence objection cannot defeat a but-for severity theory). Not a heightened standard.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
Aggravation (§ 3.306)
Regulation
38 C.F.R. § 3.306 (38 U.S.C. § 1153)
DIRECT aggravation: a pre-existing condition NOTED AT ENTRY that increased in disability during service — unless the increase is due to the natural progress of the disease. An in-service increase raises a PRESUMPTION of aggravation VA must rebut.
38 C.F.R. § 3.310(b)
SECONDARY aggravation (a distinct branch): a non-service-connected condition worsened by an already service-connected condition — see Allen.
Case law
Wagner v. Principi, 370 F.3d 1089 (Fed. Cir. 2004)
If the condition was NOT noted at entry, the veteran is presumed sound; VA must rebut BOTH pre-existence and lack of aggravation by clear and unmistakable EVIDENCE (not the CUE error doctrine). If VA fails, the claim proceeds as ordinary DIRECT service connection — not as an aggravation claim.
Horn v. Shinseki, 25 Vet. App. 231 (2012)
That rebuttal burden never shifts back to the veteran — VA must rely on affirmative evidence of no aggravation.
Hunt v. Derwinski, 1 Vet. App. 292 (1991); Davis v. Principi, 276 F.3d 1341 (Fed. Cir. 2002)
Temporary flare-ups are not aggravation — the UNDERLYING condition (not just symptoms) must have worsened.
Allen v. Brown, 7 Vet. App. 439 (1995)
Compensation is for the measurable degree of worsening over the established baseline.
38 U.S.C. § 5107(b); Gilbert v. Derwinski, 1 Vet. App. 49 (1990)
When the evidence is in relative equipoise, the tie goes to the veteran — the preponderance must be AGAINST the claim to deny it.
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